FANCB

Across TCGA patient cohorts, FANCB RNA expression is significantly associated with the protein abundance of many other proteins, with 25,166 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible FANCB-associated proteins across cancer lineages are RRM2, SMC2, and SMC4. Each is linked with FANCB in more than 9 cancer types. Because this analysis shows association rather than direction, both FANCB-to-partner and partner-to-FANCB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FANCB versus RRM2 in LSCC, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCB→partner) and Y-score (partner→FANCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RRM2 →	+0.870	+0.986	<.001	<.001	3	10
UCEC	SMC2 →	+0.750	+0.986	<.001	<.001	3	10
UCEC	SMC4 →	+0.700	+1.044	<.001	<.001	3	10
BRCA	CDC20_T70 →	+1.214	+0.738	<.001	<.001	3	10
LUAD	CDK1 →	+0.885	+0.881	<.001	<.001	3	10
OV	KPNA2 →	+0.704	+0.862	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,166 associations by consensus.

FANCB vs RRM2 — LSCC

Explore this scatter interactively →