FANCB

Across TCGA cell cohorts, FANCB mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FANCB-associated genes across cancer lineages are SCGB1D4, NXPE4, and KRTAP1-1. Each is linked with FANCB in more than 1 cancer types. Because this analysis shows association rather than direction, both FANCB-to-partner and partner-to-FANCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1D4 grouped by FANCB-low versus FANCB-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FANCB→partner) and Y-score (partner→FANCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SCGB1D4 →	+0.130	+5.169	.004	.005	3	1
BLOOD_Leukemia	NXPE4 →	+0.025	+4.276	<.001	.007	3	1
BLOOD_Leukemia	KRTAP1-1 →	+0.102	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KRTAP12-2 →	+0.072	+4.969	<.001	.003	3	1
LARGE_INTESTINE	TFDP3 →	+0.024	+4.196	<.001	.002	3	1
LARGE_INTESTINE	DPEP2NB →	+0.031	+3.920	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SCGB1D4 by FANCB expression — BREAST

Explore this box plot interactively →