Across TCGA patient cohorts, FAN1 mutation is significantly associated with the RNA expression of many other genes, with 2,378 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAN1-associated genes across cancer lineages are PINCR, ESS2, and JOSD1. Each is linked with FAN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FAN1-to-partner and partner-to-FAN1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAN1→partner) and Y-score (partner→FAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PINCR →	+0.203	+1.719	<.001	<.001	3	3
UCEC	ESS2 →	+0.267	+2.180	<.001	<.001	3	2
UCEC	JOSD1 →	+0.324	+1.643	.009	.003	3	2
UCEC	POLDIP3 →	+0.392	+1.777	.002	.003	3	2
UCEC	PPP6R2 →	+0.291	+3.021	.003	<.001	3	2
COAD	LMF2 →	+0.684	+3.499	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,378 associations by consensus.

Exploration

FAN1 survival (RNA) · tumor vs normal (RNA) · all FAN1 data types