FAM98B

Across TCGA patient cohorts, FAM98B mutation is significantly associated with the RNA expression of many other genes, with 1,414 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM98B-associated genes across cancer lineages are MIR4774, APOOP3, and SPATA31D4. Each is linked with FAM98B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM98B-to-partner and partner-to-FAM98B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4774 grouped by FAM98B-low versus FAM98B-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM98B→partner) and Y-score (partner→FAM98B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	MIR4774 →	+0.841	+6.257	<.001	.001	3	2
UCEC	APOOP3 →	+0.058	+2.421	.003	.003	3	2
HNSC	SPATA31D4 →	+0.024	+7.954	<.001	.008	3	1
HNSC	RNU6-1298P →	+0.308	+7.954	<.001	.008	3	1
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	1
READ	TMEM225 →	+0.114	+5.039	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,414 associations by consensus.

MIR4774 by FAM98B expression — READ

Explore this box plot interactively →