family with sequence similarity 8 member A3, pseudogeneGenealiases: []
Q-omics provides the consensus-scored FAM8A3P profile across patient tissues and cancer cell-line models. FAM8A3P expression is associated with patient survival in 11 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, FAM8A3P is differentially expressed in 1, with the highest sampling consensus in HNSC. Additionally, FAM8A3P RNA expression shows 5,249 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight UCEC, HNSC, and STAD as cancer lineages where FAM8A3P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM8A3P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM8A3P survival associations across molecular data types. FAM8A3P RNA expression shows survival associations in the most cancer types (11). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM8A3P RNA expression–survival associations across cancer types. High FAM8A3P expression shows unfavorable associations in UCEC, ACC, OV, MESO and LIHC, but favorable associations in GBM. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for FAM8A3P RNA expression.
This table summarizes FAM8A3P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for FAM8A3P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM8A3P shows higher tumor expression in HNSC. The HNSC box plot shows higher FAM8A3P RNA expression in tumor versus normal tissue (log2 FC = +0.021, t-test p = .034).
This table shows molecular features associated with FAM8A3P in patient tissues and cancer cell lines. In patient samples, FAM8A3P shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set.
