FAM87B

Across TCGA pan-cancer cohorts, FAM87B RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of FAM87B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM87B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM87B is over-expressed in tumor, although a few such as BRCA and UCEC show the opposite, repressed pattern.

HNSC, BRCA, and UCEC are the cancer types where FAM87B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM87B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.116	.001	9	view →
BRCA	All	III,IV	−0.298	<.001	6	view →
UCEC	All	All	−0.157	.002	6	view →
KICH	Female	All	−0.177	<.001	4	view →
KIRP	All	All	−0.079	.007	3	view →
LIHC	Female	All	+0.045	.011	3	view →
CHOL	Male	All	+0.228	.008	2	view →
PRAD	All	All	+0.178	.009	2	view →
KIRC	Male	All	+0.068	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

FAM87B–HNSC

Open the HNSC breakdown →