family with sequence similarity 87 member BGenealiases: []
Q-omics provides the consensus-scored FAM87B profile across patient tissues and cancer cell-line models. FAM87B expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in LGG. Among the 18 cancer types available for tumor–normal comparison, FAM87B is differentially expressed in 9, with the highest sampling consensus in HNSC. Additionally, FAM87B RNA expression shows 16,727 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight LGG, HNSC, and UVM as cancer lineages where FAM87B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM87B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM87B survival associations across molecular data types. FAM87B RNA expression shows survival associations in the most cancer types (23). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM87B RNA expression–survival associations across cancer types. High FAM87B expression shows unfavorable associations in LGG, MESO, KIRC, BLCA and THCA, but favorable associations in CHOL. The LGG Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify LGG as the clearest survival context for FAM87B RNA expression.
This table summarizes FAM87B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for FAM87B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM87B shows lower tumor expression in BRCA, UCEC, KICH and KIRP and higher tumor expression in HNSC and LIHC. The HNSC box plot shows higher FAM87B RNA expression in tumor versus normal tissue (log2 FC = +0.116, t-test p = .001).
This table shows molecular features associated with FAM87B in patient tissues and cancer cell lines. In patient samples, FAM87B shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set.
