FAM83H

Across TCGA pan-cancer cohorts, FAM83H mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FAM83H data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FAM83H mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated FAM83H expression acts as an unfavorable survival marker, although some lineages such as LUAD and UCEC show a favorable association.

LUAD, UCEC, and PDAC are the cancer types where FAM83H mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.923	.002	35	view →
UCEC	DFS	Median	II,III,IV	0.944	0.482	.004	28	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	25	view →
COAD	DFS	Tertile	II,III,IV	1.000	0.862	.031	24	view →
CCRCC	OS	Median	All	0.652	1.000	.008	13	view →
HNSC	DFS	Median	IV	0.889	0.407	.042	3	view →
GBM	OS	Tertile	All	0.239	0.536	.047	2	view →
LSCC	DFS	Quartile	All	0.557	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FAM83H–LUAD (OS)

Open the LUAD breakdown →