FAM83H

Across TCGA patient cohorts, FAM83H mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM83H-associated genes across cancer lineages are ATM, Dvl3, and GAPDH. Each is linked with FAM83H in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM83H-to-partner and partner-to-FAM83H results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FAM83H-low versus FAM83H-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83H→partner) and Y-score (partner→FAM83H) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.772	-3.459	<.001	.004	3	3
COAD	Dvl3 →	-0.286	-1.991	<.001	.031	3	3
UCEC	GAPDH →	+0.444	+1.906	.019	.015	3	3
UCEC	mTOR_pS2448 →	-0.146	-1.980	.005	.009	3	3
COAD	eIF4E →	+0.210	+3.012	.003	.018	3	2
COAD	SCD →	+0.113	+2.042	.044	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

ATM by FAM83H expression — COAD

Explore this box plot interactively →