FAM83E

Across TCGA pan-cancer cohorts, FAM83E Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FAM83E data layer compared with 25 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM83E Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM83E expression acts as an unfavorable survival marker.

HNSC, BLCA, and UCEC are the cancer types where FAM83E Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.710	.002	24	view →
BLCA	OS	Median	All	0.188	0.687	.020	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FAM83E–HNSC (OS)

Open the HNSC breakdown →