FAM83E

Across TCGA pan-cancer cohorts, FAM83E mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FAM83E data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher FAM83E mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM83E expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where FAM83E mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.789	0.988	.008	13	view →
PDAC	DFS	Quartile	All	0.774	0.356	.009	8	view →
UCEC	DFS	Tertile	III,IV	0.172	1.000	.024	8	view →
LSCC	OS	Median	All	1.000	0.793	.031	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FAM83E–LUAD (DFS)

Open the LUAD breakdown →