FAM83E

Across TCGA pan-cancer cohorts, FAM83E mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of FAM83E’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where FAM83E mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types FAM83E is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

LSCC, PDAC, and HNSC are the cancer types where FAM83E tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83E mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	II,III,IV	−0.465	<.001	4	view →
PDAC	All	All	+0.509	.004	3	view →
HNSC	All	All	−0.322	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

FAM83E–LSCC

Open the LSCC breakdown →