FAM83C

Across TCGA patient cohorts, FAM83C mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM83C-associated genes across cancer lineages are Cyclin-B1, ACC_pS79, and p70-S6K. Each is linked with FAM83C in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM83C-to-partner and partner-to-FAM83C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FAM83C-low versus FAM83C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83C→partner) and Y-score (partner→FAM83C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.504	+1.765	.016	.014	3	3
LUAD	ACC_pS79 →	+0.363	+2.321	.026	.035	3	2
LUAD	p70-S6K →	+0.217	+3.000	.032	.034	3	2
UCEC	FOXO3a_pS318_S321 →	-0.157	-1.765	<.001	.014	3	2
UCEC	JNK_pT183_Y185 →	-0.228	-2.649	<.001	<.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.649	-3.906	<.001	<.001	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Cyclin-B1 by FAM83C expression — UCEC

Explore this box plot interactively →