FAM83C

Across TCGA pan-cancer cohorts, FAM83C RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of FAM83C’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where FAM83C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM83C is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

LUSC, KIRP, and PAAD are the cancer types where FAM83C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Female	II,III,IV	+4.002	<.001	8	view →
KIRP	Male	III,IV	−0.066	.008	6	view →
PAAD	All	All	+0.114	.005	4	view →
KIRC	Male	All	−0.034	<.001	3	view →
BLCA	Male	All	+1.675	.042	2	view →
PRAD	All	All	−0.590	<.001	2	view →
UCEC	All	All	+0.206	.001	2	view →
THCA	Male	III,IV	−0.020	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

FAM83C–LUSC

Open the LUSC breakdown →