FAM83C

Across TCGA cell cohorts, FAM83C mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM83C-associated genes across cancer lineages are PRR30, HDGFL1, and GCM2. Each is linked with FAM83C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM83C-to-partner and partner-to-FAM83C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR30 grouped by FAM83C-low versus FAM83C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83C→partner) and Y-score (partner→FAM83C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRR30 →	+0.021	+4.269	<.001	.002	3	2
SOFT_TISSUE	HDGFL1 →	+0.534	+3.635	<.001	.007	3	1
SOFT_TISSUE	GCM2 →	+0.013	+3.999	.006	.004	3	1
SOFT_TISSUE	GSX1 →	+0.137	+3.882	<.001	.004	3	1
URINARY_TRACT	OPRPN →	+0.060	+5.087	<.001	.004	3	1
BLOOD_Leukemia	GML →	+0.077	+4.567	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

PRR30 by FAM83C expression — BLOOD_Leukemia

Explore this box plot interactively →