FAM83B

Across TCGA patient cohorts, FAM83B mutation is significantly associated with the RNA expression of many other genes, with 5,747 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM83B-associated genes across cancer lineages are LEO1, C18orf54, and NIPA1. Each is linked with FAM83B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM83B-to-partner and partner-to-FAM83B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LEO1 grouped by FAM83B-low versus FAM83B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83B→partner) and Y-score (partner→FAM83B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LEO1 →	+0.385	+1.488	<.001	<.001	3	3
UCEC	C18orf54 →	+0.413	+1.209	<.001	.003	3	3
UCEC	NIPA1 →	+0.803	+2.125	<.001	<.001	3	3
UCEC	FANCB →	+0.268	+1.536	.003	.001	3	3
UCEC	RPL23AP82 →	+0.424	+1.632	<.001	<.001	3	3
SKCM	KRT5 →	-1.155	-1.452	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,747 associations by consensus.

LEO1 by FAM83B expression — UCEC

Explore this box plot interactively →