FAM83B

Across TCGA pan-cancer cohorts, FAM83B RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated FAM83B data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher FAM83B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM83B expression acts as an unfavorable survival marker, although some lineages such as OV and ESCA show a favorable association.

UVM, LUAD, and KIRP are the cancer types where FAM83B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.347	0.668	.006	108	view →
LUAD	DFS	Quartile	All	0.151	0.471	<.001	87	view →
KIRP	DFS	Quartile	All	0.739	0.916	.001	65	view →
PAAD	OS	Tertile	All	0.388	0.653	.001	54	view →
BLCA	OS	Median	IV	0.504	0.664	.004	42	view →
OV	OS	Tertile	All	0.897	0.808	.003	38	view →
MESO	OS	Quartile	III,IV	0.428	0.716	.012	27	view →
SKCM	OS	Quartile	All	0.328	0.466	.004	27	view →
ESCA	DFS	Tertile	III,IV	0.534	0.310	.022	27	view →
UCEC	OS	Quartile	All	0.829	0.923	.006	18	view →
PRAD	DFS	Median	All	0.858	0.712	.005	18	view →
READ	OS	Median	II,III,IV	0.915	0.458	.004	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

FAM83B–UVM (OS)

Open the UVM breakdown →