FAM83B

Across TCGA patient cohorts, FAM83B mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM83B-associated genes across cancer lineages are Caspase-7-cleavedD198, IGFBP2, and p27_pT157. Each is linked with FAM83B in more than 3 cancer types. Because this analysis shows association rather than direction, both FAM83B-to-partner and partner-to-FAM83B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FAM83B-low versus FAM83B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83B→partner) and Y-score (partner→FAM83B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.753	+2.321	<.001	<.001	3	4
LUSC	IGFBP2 →	-0.982	-3.000	.002	.035	3	2
LUSC	p27_pT157 →	+0.094	+1.901	.011	.030	3	2
LUSC	Collagen-VI →	-0.245	-3.169	.048	.018	3	2
LUAD	HER3_pY1289 →	+0.075	+1.597	.046	.040	3	2
UCEC	MEK1 →	+0.416	+3.247	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Caspase-7-cleavedD198 by FAM83B expression — UCEC

Explore this box plot interactively →