FAM83A

Across TCGA pan-cancer cohorts, FAM83A Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FAM83A data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher FAM83A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM83A expression acts as an unfavorable survival marker.

THYM, OV, and LUAD are the cancer types where FAM83A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
OV	DFS	Median	II,III,IV	0.220	0.542	.011	18	view →
LUAD	DFS	Median	All	0.327	0.668	.005	14	view →
PRAD	DFS	Median	All	0.068	0.935	<.001	6	view →
LIHC	OS	Median	All	0.098	0.774	.001	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FAM83A–THYM (OS)

Open the THYM breakdown →