FAM83A

Across TCGA pan-cancer cohorts, FAM83A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of FAM83A’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where FAM83A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM83A is over-expressed in tumor, although a few such as KIRC and PRAD show the opposite, repressed pattern.

LUAD, LUSC, and HNSC are the cancer types where FAM83A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM83A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+6.430	<.001	9	view →
LUSC	All	II,III,IV	+3.501	<.001	8	view →
HNSC	Female	III,IV	+2.182	.001	8	view →
COAD	All	II,III,IV	+0.373	<.001	7	view →
THCA	All	All	+0.631	<.001	6	view →
BLCA	Male	All	+3.588	.004	4	view →
BRCA	Female	II,III,IV	+0.774	<.001	4	view →
KIRC	All	All	−0.139	.022	3	view →
PAAD	All	All	+4.037	.012	2	view →
PRAD	All	All	−0.746	<.001	2	view →
KICH	Female	All	−0.160	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

FAM83A–LUAD

Open the LUAD breakdown →