FAM83A

Across TCGA pan-cancer cohorts, FAM83A mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FAM83A data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FAM83A mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM83A expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where FAM83A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.254	0.564	<.001	43	view →
HNSC	OS	Median	II,III,IV	0.992	0.932	.019	24	view →
LUAD	DFS	Median	All	0.512	0.769	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FAM83A–PDAC (DFS)

Open the PDAC breakdown →