FAM83A

Across TCGA patient cohorts, FAM83A mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM83A-associated genes across cancer lineages are C-Raf, Annexin-1, and Shc_pY317. Each is linked with FAM83A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM83A-to-partner and partner-to-FAM83A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by FAM83A-low versus FAM83A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83A→partner) and Y-score (partner→FAM83A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.272	+3.321	<.001	.010	3	2
UCEC	Annexin-1 →	+0.646	+3.019	.008	.019	3	1
UCEC	Shc_pY317 →	-0.154	-2.584	.029	.011	3	1
UCEC	Tuberin →	+0.328	+2.179	.008	.034	3	1
UCEC	ASNS →	+0.577	+3.321	<.001	.010	2	2
UCEC	c-Met_pY1235 →	+0.068	+2.179	.048	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

C-Raf by FAM83A expression — UCEC

Explore this box plot interactively →