FAM83A

Across TCGA cell cohorts, FAM83A mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM83A-associated genes across cancer lineages are LYZL1, OR2T1, and TPPP2. Each is linked with FAM83A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM83A-to-partner and partner-to-FAM83A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL1 grouped by FAM83A-low versus FAM83A-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM83A→partner) and Y-score (partner→FAM83A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LYZL1 →	+0.036	+6.247	<.001	<.001	3	1
SKIN	OR2T1 →	+0.010	+5.022	<.001	.002	3	1
SKIN	TPPP2 →	+0.054	+5.217	<.001	<.001	3	1
SKIN	OTOG →	+0.064	+4.684	<.001	.002	3	1
BLOOD_Leukemia	PPP1R2C →	+0.307	+5.539	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.062	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

LYZL1 by FAM83A expression — BLOOD_Lymphoma

Explore this box plot interactively →