Across TCGA patient cohorts, FAM78B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM78B-associated genes across cancer lineages are EGFR_pY1068, EGFR, and eIF4E. Each is linked with FAM78B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM78B-to-partner and partner-to-FAM78B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM78B→partner) and Y-score (partner→FAM78B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.343	-3.584	.004	.002	3	1
UCEC	EGFR →	-0.258	-3.000	<.001	.036	3	1
UCEC	eIF4E →	+0.288	+3.013	.004	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.147	-2.999	.014	.035	3	1
UCEC	GAPDH →	+0.640	+2.459	.013	.020	3	1
UCEC	JNK_pT183_Y185 →	-0.256	-3.571	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

FAM78B survival (RNA) · tumor vs normal (RNA) · all FAM78B data types