Across TCGA pan-cancer cohorts, FAM78B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated FAM78B data layer compared with 6 for mutation status.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FAM78B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM78B expression acts as an unfavorable survival marker, although some lineages such as ESCA and PAAD show a favorable association.
KIRC, KIRP, and ESCA are the cancer types where FAM78B RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.