FAM78A

Across TCGA patient cohorts, FAM78A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM78A-associated genes across cancer lineages are MEK1, Shc_pY317, and EGFR. Each is linked with FAM78A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM78A-to-partner and partner-to-FAM78A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by FAM78A-low versus FAM78A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM78A→partner) and Y-score (partner→FAM78A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.363	+2.700	.006	.006	3	2
UCEC	Shc_pY317 →	-0.129	-1.847	.021	.008	3	2
UCEC	EGFR →	-0.178	-2.584	.002	.010	3	1
UCEC	JNK2 →	+0.180	+2.196	.013	.032	3	1
UCEC	MSH6 →	-0.390	-1.700	.001	.040	3	1
UCEC	Notch1 →	+0.183	+2.247	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MEK1 by FAM78A expression — UCEC

Explore this box plot interactively →