FAM78A

Across TCGA pan-cancer cohorts, FAM78A RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FAM78A data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM78A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated FAM78A expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, UVM, and CESC are the cancer types where FAM78A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.379	0.254	<.001	138	view →
UVM	DFS	Tertile	II,III,IV	0.457	0.802	.003	63	view →
CESC	DFS	Median	II,III,IV	0.874	0.673	.002	58	view →
LUAD	OS	Tertile	III,IV	0.677	0.301	<.001	57	view →
UCEC	OS	Tertile	IV	0.737	0.329	.013	50	view →
LGG	DFS	Median	All	0.331	0.465	<.001	42	view →
PAAD	OS	Median	II,III,IV	0.644	0.464	.015	19	view →
LUSC	DFS	Tertile	III,IV	0.219	0.845	.015	19	view →
LAML	DFS	Median	All	0.252	0.486	.008	18	view →
STAD	DFS	Tertile	II,III,IV	0.690	0.554	.012	13	view →
UCS	OS	Quartile	III,IV	0.638	0.278	.028	12	view →
CHOL	DFS	Tertile	All	0.690	0.177	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FAM78A–HNSC (DFS)

Open the HNSC breakdown →