FAM78A

Across TCGA cell cohorts, FAM78A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,427 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM78A-associated GO terms across cancer lineages are Positive regulation of DNA repair, Negative regulation of transcription initiation-coupled chromatin remodeling, and Negative regulation of cholesterol efflux. Each is linked with FAM78A in more than 8 cancer types. Because this analysis shows association rather than direction, both FAM78A-to-partner and partner-to-FAM78A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by FAM78A-low versus FAM78A-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM78A→partner) and Y-score (partner→FAM78A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of DNA repair →	+0.062	+0.726	.002	<.001	3	9
SOFT_TISSUE	Negative regulation of transcription initiation-coupled chromatin remodeling →	+0.172	+0.709	<.001	.007	3	9
URINARY_TRACT	Negative regulation of cholesterol efflux →	+0.278	+0.861	<.001	<.001	3	9
STOMACH	Positive regulation of potassium ion import across plasma membrane →	-0.237	-1.038	<.001	<.001	3	9
LUNG_NSCLC_LUAD	Regulation of antigen processing and presentation →	-0.155	-0.828	<.001	.002	3	8
BONE	Fat cell proliferation →	-0.300	-0.685	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,427 associations by consensus.

Positive regulation of DNA repair by FAM78A expression — BONE

Explore this box plot interactively →