FAM74A6

Across TCGA patient cohorts, FAM74A6 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,130 significant associations in total. STAD shows the largest number of these associations.

The most reproducible FAM74A6-associated GO terms across cancer lineages are Axonemal dynein complex assembly, Intraciliary transport, and Microtubule bundle formation. Each is linked with FAM74A6 in more than 6 cancer types. Because this analysis shows association rather than direction, both FAM74A6-to-partner and partner-to-FAM74A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Axonemal dynein complex assembly grouped by FAM74A6-low versus FAM74A6-high in LGG.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM74A6→partner) and Y-score (partner→FAM74A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	Axonemal dynein complex assembly →	+0.124	+0.051	<.001	.007	3	7
UCEC	Intraciliary transport →	+0.067	+0.012	<.001	<.001	3	7
LUAD	Microtubule bundle formation →	+0.072	+0.011	<.001	<.001	3	6
STAD	Negative regulation of cytoskeleton organization →	+0.071	+0.011	<.001	<.001	3	6
LUAD	Regulation of microtubule-based movement →	+0.041	+0.015	<.001	<.001	3	5
OV	Establishment of left/right asymmetry →	+0.125	+0.006	<.001	.005	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,130 associations by consensus.

Axonemal dynein complex assembly by FAM74A6 expression — LGG

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