FAM74A6

Across TCGA pan-cancer cohorts, FAM74A6 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated FAM74A6 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher FAM74A6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated FAM74A6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LAML show a favorable association.

KIRC, UCS, and UCEC are the cancer types where FAM74A6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	IV	0.167	0.605	<.001	132	view →
UCS	OS	Tertile	III,IV	0.102	0.591	<.001	90	view →
UCEC	DFS	Tertile	II,III,IV	0.170	0.614	.009	60	view →
THCA	OS	Tertile	IV	0.626	1.000	.002	54	view →
UVM	DFS	Tertile	All	0.079	0.746	<.001	54	view →
LGG	DFS	Tertile	All	0.441	0.750	<.001	54	view →
PCPG	OS	Tertile	All	0.032	0.948	<.001	36	view →
BLCA	OS	Tertile	III,IV	0.164	0.587	.002	27	view →
ESCA	DFS	Tertile	All	0.414	0.791	.015	27	view →
STAD	OS	Tertile	III,IV	0.278	0.667	.002	27	view →
THYM	OS	Tertile	II,III,IV	0.352	0.855	.006	18	view →
HNSC	OS	Tertile	II,III,IV	1.000	0.735	.023	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

FAM74A6–KIRC (DFS)

Open the KIRC breakdown →