FAM74A6

Across TCGA patient cohorts, FAM74A6 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM74A6-associated genes across cancer lineages are F8A2, RNA5SP205, and SNORD115-45. Each is linked with FAM74A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM74A6-to-partner and partner-to-FAM74A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, F8A2 grouped by FAM74A6-low versus FAM74A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM74A6→partner) and Y-score (partner→FAM74A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	F8A2 →	+0.074	+5.694	<.001	.003	3	1
UCEC	RNA5SP205 →	+0.607	+5.852	<.001	.003	3	1
UCEC	SNORD115-45 →	+0.689	+5.186	<.001	.007	3	1
UCEC	MIR1266 →	+0.638	+5.771	<.001	.003	3	1
UCEC	LINC02353 →	+0.361	+5.484	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

F8A2 by FAM74A6 expression — UCEC

Explore this box plot interactively →