family with sequence similarity 74 member A4Genealiases: []
Q-omics provides the consensus-scored FAM74A4 profile across patient tissues and cancer cell-line models. FAM74A4 expression is associated with patient survival in 12 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, FAM74A4 is differentially expressed in 3, with the highest sampling consensus in LUAD. Additionally, FAM74A4 RNA expression shows 9,458 significant gene co-expression associations, with the highest sampling consensus in COAD. Together, these results highlight ACC, LUAD, and COAD as cancer lineages where FAM74A4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM74A4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM74A4 survival associations across molecular data types. FAM74A4 RNA expression shows survival associations in the most cancer types (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM74A4 RNA expression–survival associations across cancer types. High FAM74A4 expression shows unfavorable associations in ACC, ESCA, UCEC, LGG, STAD and LAML. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for FAM74A4 RNA expression.
This table summarizes FAM74A4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 3. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for FAM74A4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM74A4 shows lower tumor expression in LUAD, LUSC and LIHC. The LUAD box plot shows higher FAM74A4 RNA expression in normal versus tumor tissue (log2 FC = −0.015, t-test p = .044).
This table shows molecular features associated with FAM74A4 in patient tissues and cancer cell lines. In patient samples, FAM74A4 shows the broadest associations at the RNA and protein expression levels, with COAD recurring as the lineage with the largest associated feature set.
