FAM72C

Across TCGA pan-cancer cohorts, FAM72C RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of FAM72C’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where FAM72C RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM72C is over-expressed in tumor.

HNSC, BLCA, and KIRC are the cancer types where FAM72C tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM72C RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.507	<.001	12	view →
BLCA	All	III,IV	+0.957	<.001	10	view →
KIRC	Male	IV	+0.205	<.001	10	view →
LUAD	Male	II,III,IV	+0.564	<.001	9	view →
LUSC	Male	II,III,IV	+0.755	<.001	8	view →
STAD	All	All	+0.540	<.001	8	view →
LIHC	Male	II,III,IV	+0.368	<.001	8	view →
KIRP	Male	III,IV	+0.142	<.001	8	view →
UCEC	All	II,III,IV	+0.667	<.001	6	view →
BRCA	All	II,III,IV	+0.371	<.001	6	view →
COAD	All	All	+0.156	.006	4	view →
ESCA	All	All	+0.735	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

FAM72C–HNSC

Open the HNSC breakdown →