FAM71E2

Across TCGA pan-cancer cohorts, FAM71E2 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated FAM71E2 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher FAM71E2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated FAM71E2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and THYM show a favorable association.

HNSC, THYM, and CESC are the cancer types where FAM71E2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.554	0.299	.001	77	view →
THYM	DFS	Tertile	All	0.975	0.804	.003	45	view →
CESC	OS	Tertile	IV	0.809	0.230	<.001	30	view →
LUAD	DFS	Tertile	All	0.723	0.808	.009	21	view →
THCA	DFS	Tertile	III,IV	0.107	0.634	.003	18	view →
ACC	DFS	Tertile	All	0.084	0.454	.024	18	view →
LGG	DFS	Tertile	All	0.642	0.764	.005	18	view →
BLCA	DFS	Tertile	IV	0.217	0.522	.012	12	view →
STAD	DFS	Tertile	All	0.537	0.726	.019	12	view →
KIRC	DFS	Tertile	IV	0.291	0.521	.049	12	view →
MESO	DFS	Median	IV	0.176	0.481	.005	6	view →
SKCM	OS	Tertile	III,IV	0.682	0.852	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

FAM71E2–HNSC (OS)

Open the HNSC breakdown →