FAM71D

Across TCGA patient cohorts, FAM71D mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM71D-associated genes across cancer lineages are eEF2, NDRG1_pT346, and TFRC. Each is linked with FAM71D in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM71D-to-partner and partner-to-FAM71D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by FAM71D-low versus FAM71D-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM71D→partner) and Y-score (partner→FAM71D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eEF2 →	+0.447	+2.700	.002	.006	3	2
SKCM	NDRG1_pT346 →	-0.828	-3.169	.004	.018	3	2
SKCM	TFRC →	+0.492	+1.874	.048	.049	3	2
UCEC	GATA6 →	-0.114	-1.655	.037	.011	3	2
UCEC	Ku80 →	+0.278	+2.916	<.001	<.001	3	2
UCEC	Annexin-1 →	+0.551	+2.827	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

eEF2 by FAM71D expression — SKCM

Explore this box plot interactively →