FAM71A

Across TCGA patient cohorts, FAM71A mutation is significantly associated with the RNA expression of many other genes, with 3,234 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible FAM71A-associated genes across cancer lineages are PKN3, GLRX5, and CDCA2. Each is linked with FAM71A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM71A-to-partner and partner-to-FAM71A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKN3 grouped by FAM71A-low versus FAM71A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM71A→partner) and Y-score (partner→FAM71A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKN3 →	+0.862	+4.032	<.001	<.001	3	3
UCEC	GLRX5 →	+0.363	+2.119	.004	.003	3	3
UCEC	CDCA2 →	+0.647	+2.823	.003	.001	3	3
UCEC	CA15P1 →	+0.177	+2.569	.002	<.001	3	3
LUAD	MTATP6P21 →	+0.205	+5.011	<.001	.002	3	3
UCEC	MTMR10 →	+0.356	+1.947	.004	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,234 associations by consensus.

PKN3 by FAM71A expression — UCEC

Explore this box plot interactively →