FAM71A

Across TCGA patient cohorts, FAM71A mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM71A-associated genes across cancer lineages are Annexin-1, S6_pS240_S244, and Caspase-8. Each is linked with FAM71A in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM71A-to-partner and partner-to-FAM71A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by FAM71A-low versus FAM71A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM71A→partner) and Y-score (partner→FAM71A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.625	+2.604	.001	.005	3	3
UCEC	S6_pS240_S244 →	+0.337	+2.459	.027	.019	3	2
UCEC	Caspase-8 →	-0.287	-3.880	.002	<.001	3	2
UCEC	Cyclin-B1 →	+0.517	+1.765	.014	.014	3	2
SKCM	XBP1 →	-0.224	-3.169	.016	.017	3	2
BLCA	Claudin-7 →	+1.020	+3.000	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Annexin-1 by FAM71A expression — UCEC

Explore this box plot interactively →