FAM71A

Across TCGA cell cohorts, FAM71A mutation is significantly associated with the drug of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM71A-associated genes across cancer lineages are Methotrexate, Pevonedistat, and AT-7519. Each is linked with FAM71A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM71A-to-partner and partner-to-FAM71A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Methotrexate grouped by FAM71A-low versus FAM71A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM71A→partner) and Y-score (partner→FAM71A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Methotrexate →	+0.895	+2.807	.023	.046	3	1
LARGE_INTESTINE	Pevonedistat →	+0.814	+2.871	.011	.021	3	1
LARGE_INTESTINE	AT-7519 →	+0.893	+3.000	.008	.020	3	1
LARGE_INTESTINE	GSK429286A →	+0.292	+3.067	.040	.009	3	1
LARGE_INTESTINE	WZ3105 →	+0.739	+3.067	.017	.009	3	1
LARGE_INTESTINE	PHA-793887 →	+0.857	+3.067	.008	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Methotrexate by FAM71A expression — LARGE_INTESTINE

Explore this box plot interactively →