FAM53C

Across TCGA patient cohorts, FAM53C protein abundance is significantly associated with the RNA expression of many other genes, with 3,256 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FAM53C-associated genes across cancer lineages are DBN1, SLC9A3R1, and TTC9. Each is linked with FAM53C in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM53C-to-partner and partner-to-FAM53C results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FAM53C versus DBN1 in HNSC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53C→partner) and Y-score (partner→FAM53C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DBN1 →	+1.365	+0.686	.004	.003	3	3
BRCA	SLC9A3R1 →	-1.122	-0.405	.001	<.001	3	2
LSCC	TTC9 →	-1.011	-0.293	<.001	<.001	3	2
UCEC	TCF23 →	+1.075	+0.388	<.001	.007	3	2
UCEC	RNU6-1061P →	-1.387	-0.465	.001	.007	3	2
LUAD	TBCA →	+0.517	+0.599	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,256 associations by consensus.

FAM53C vs DBN1 — HNSC

Explore this scatter interactively →