FAM53C

Across TCGA cell cohorts, FAM53C mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FAM53C-associated genes across cancer lineages are USP17L20 and USP17L18. Each is linked with FAM53C in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM53C-to-partner and partner-to-FAM53C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP17L20 grouped by FAM53C-low versus FAM53C-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53C→partner) and Y-score (partner→FAM53C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	USP17L20 →	+0.006	+5.539	<.001	.003	3	1
BLOOD_Leukemia	USP17L18 →	+0.006	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

USP17L20 by FAM53C expression — BLOOD_Leukemia

Explore this box plot interactively →