FAM53B-AS1

Across TCGA pan-cancer cohorts, FAM53B-AS1 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated FAM53B-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher FAM53B-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM53B-AS1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and STAD show a favorable association.

UVM, BRCA, and STAD are the cancer types where FAM53B-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	All	0.456	0.913	.003	75	view →
BRCA	OS	Tertile	III,IV	0.923	0.745	<.001	56	view →
STAD	OS	Tertile	III,IV	0.733	0.524	.002	45	view →
PAAD	OS	Quartile	II,III,IV	0.701	0.468	.003	44	view →
LGG	OS	Tertile	All	0.380	0.596	<.001	39	view →
HNSC	OS	Quartile	II,III,IV	0.496	0.315	.005	33	view →
READ	DFS	Quartile	All	0.233	0.660	.005	33	view →
LUSC	OS	Median	II,III,IV	0.925	0.621	<.001	30	view →
LUAD	OS	Median	III,IV	0.767	0.542	.004	28	view →
DLBC	OS	Tertile	II,III,IV	1.000	0.415	.010	25	view →
UCS	DFS	Median	II,III,IV	0.594	0.296	.011	22	view →
SKCM	DFS	Quartile	II,III,IV	0.839	0.600	.011	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

FAM53B-AS1–UVM (OS)

Open the UVM breakdown →