FAM53B-AS1

Across TCGA pan-cancer cohorts, FAM53B-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM53B-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where FAM53B-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types FAM53B-AS1 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and LUSC are the cancer types where FAM53B-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM53B-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−0.200	<.001	10	view →
KIRC	Male	All	−0.153	<.001	7	view →
LUSC	All	All	−0.069	<.001	5	view →
READ	All	III,IV	−0.290	.004	4	view →
UCEC	All	All	−0.212	.005	4	view →
HNSC	Male	All	−0.069	.012	4	view →
KICH	All	All	+0.324	.002	3	view →
THCA	Male	III,IV	−0.164	.011	3	view →
BRCA	All	III,IV	−0.103	.025	2	view →
LUAD	Female	II,III,IV	−0.094	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM53B-AS1–KIRP

Open the KIRP breakdown →