FAM53A

Across TCGA pan-cancer cohorts, FAM53A Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated FAM53A data layer compared with 28 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher FAM53A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FAM53A expression acts as an unfavorable survival marker.

THYM and COAD are the cancer types where FAM53A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.585	0.879	.002	12	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

FAM53A–THYM (OS)

Open the THYM breakdown →