FAM53A

Across TCGA cell cohorts, FAM53A RNA expression is significantly associated with the go_rna of many other GO terms, with 3,140 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FAM53A-associated GO terms across cancer lineages are Transcription pausing by RNA polymerase II, Protein localization to cilium, and Intraciliary anterograde transport. Each is linked with FAM53A in more than 8 cancer types. Because this analysis shows association rather than direction, both FAM53A-to-partner and partner-to-FAM53A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transcription pausing by RNA polymerase II grouped by FAM53A-low versus FAM53A-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53A→partner) and Y-score (partner→FAM53A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Transcription pausing by RNA polymerase II →	+0.068	+0.449	.002	<.001	3	9
STOMACH	Protein localization to cilium →	+0.048	+0.812	.002	.003	2	9
LUNG_NSCLC_LUSC	Intraciliary anterograde transport →	+0.065	+0.707	.004	.006	2	9
URINARY_TRACT	Transport along microtubule →	+0.048	+0.752	.003	.004	3	8
BONE	Positive regulation of double-strand break repair →	+0.058	+0.744	.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Epigenetic regulation of gene expression →	+0.056	+0.899	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,140 associations by consensus.

Transcription pausing by RNA polymerase II by FAM53A expression — LARGE_INTESTINE

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