FAM53A

Across TCGA cell cohorts, FAM53A mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FAM53A-associated genes across cancer lineages are FTMT, OR2L8, and FCGR3B. Each is linked with FAM53A in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM53A-to-partner and partner-to-FAM53A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by FAM53A-low versus FAM53A-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM53A→partner) and Y-score (partner→FAM53A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.065	+4.977	<.001	.002	3	1
SOFT_TISSUE	OR2L8 →	+0.029	+4.369	<.001	.008	3	1
LARGE_INTESTINE	FCGR3B →	+0.174	+4.467	<.001	.004	3	1
LARGE_INTESTINE	CENPVL1 →	+0.211	+4.095	<.001	.009	3	1
LARGE_INTESTINE	F11 →	+0.075	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FTMT by FAM53A expression — SOFT_TISSUE

Explore this box plot interactively →