FAM50B

Across TCGA patient cohorts, FAM50B mutation is significantly associated with the RNA expression of many other genes, with 2,505 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM50B-associated genes across cancer lineages are PCBP1-AS1, NOP10, and NGRN. Each is linked with FAM50B in more than 2 cancer types. Because this analysis shows association rather than direction, both FAM50B-to-partner and partner-to-FAM50B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCBP1-AS1 grouped by FAM50B-low versus FAM50B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM50B→partner) and Y-score (partner→FAM50B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCBP1-AS1 →	+0.372	+1.971	<.001	.007	2	3
UCEC	NOP10 →	+0.443	+2.950	<.001	<.001	3	2
UCEC	NGRN →	+0.476	+2.606	<.001	<.001	3	2
CESC	RNU6-74P →	+0.470	+5.201	<.001	.007	3	2
UCEC	LINC02340 →	+0.237	+2.191	.006	.002	3	2
UCEC	RNA5SP412 →	+0.639	+1.896	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,505 associations by consensus.

PCBP1-AS1 by FAM50B expression — UCEC

Explore this box plot interactively →