FAM50B

Across TCGA pan-cancer cohorts, FAM50B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of FAM50B’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where FAM50B RNA is repressed in tumor relative to normal tissue. In most cancer types FAM50B is over-expressed in tumor, although a few such as THCA and BLCA show the opposite, repressed pattern.

THCA, BLCA, and KICH are the cancer types where FAM50B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM50B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.844	<.001	10	view →
BLCA	Male	IV	−2.985	<.001	9	view →
KICH	Male	All	−2.051	<.001	9	view →
UCEC	All	II,III,IV	−1.941	<.001	6	view →
BRCA	Female	II,III,IV	−0.503	<.001	6	view →
COAD	Male	II,III,IV	−1.031	<.001	4	view →
READ	All	All	−1.290	.012	2	view →
PRAD	All	All	−0.340	.006	2	view →
KIRP	All	All	−0.664	.017	1	view →
KIRC	Female	All	+0.334	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

FAM50B–THCA

Open the THCA breakdown →