FAM50B

Across TCGA patient cohorts, FAM50B mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FAM50B-associated genes across cancer lineages are Myosin-IIa_pS1943, Notch1, and Annexin-1. Each is linked with FAM50B in more than 1 cancer types. Because this analysis shows association rather than direction, both FAM50B-to-partner and partner-to-FAM50B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa_pS1943 grouped by FAM50B-low versus FAM50B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FAM50B→partner) and Y-score (partner→FAM50B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa_pS1943 →	+0.143	+1.820	.041	.002	3	2
UCEC	Notch1 →	+0.170	+1.820	<.001	.014	3	2
UCEC	Annexin-1 →	+0.634	+2.321	<.001	.005	3	2
UCEC	C-Raf →	+0.184	+1.807	<.001	.004	3	2
UCEC	EGFR_pY1068 →	-0.171	-1.514	.046	.015	3	1
UCEC	eIF4E →	+0.154	+3.598	.032	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Myosin-IIa_pS1943 by FAM50B expression — UCEC

Explore this box plot interactively →