FAM50A

Across TCGA pan-cancer cohorts, FAM50A RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated FAM50A data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher FAM50A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FAM50A expression acts as an unfavorable survival marker, although some lineages such as SCLC and CHOL show a favorable association.

UVM, ACC, and KICH are the cancer types where FAM50A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.403	0.833	<.001	118	view →
ACC	DFS	Median	All	0.228	0.679	<.001	100	view →
KICH	OS	Tertile	II,III,IV	0.319	0.913	.001	73	view →
MESO	OS	Tertile	III,IV	0.391	0.750	<.001	69	view →
COAD	DFS	Tertile	All	0.624	0.785	.001	64	view →
LIHC	OS	Median	All	0.577	0.788	<.001	57	view →
KIRC	DFS	Quartile	All	0.812	0.908	.004	39	view →
KIRP	OS	Median	II,III,IV	0.595	0.870	.002	36	view →
SCLC	OS	Quartile	All	0.856	0.516	.004	33	view →
LGG	DFS	Median	All	0.656	0.804	<.001	32	view →
BRCA	OS	Median	All	0.948	0.975	.002	31	view →
LAML	DFS	Median	All	0.449	0.673	.002	30	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

FAM50A–UVM (OS)

Open the UVM breakdown →