FAM50A

Across TCGA pan-cancer cohorts, FAM50A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of FAM50A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where FAM50A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FAM50A is over-expressed in tumor.

KIRC, COAD, and KIRP are the cancer types where FAM50A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in FAM50A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.784	<.001	12	view →
COAD	Female	All	+1.086	<.001	11	view →
KIRP	All	II,III,IV	+0.928	<.001	11	view →
LIHC	Male	II,III,IV	+1.878	<.001	9	view →
STAD	Male	II,III,IV	+1.165	<.001	8	view →
BLCA	All	All	+0.518	.002	7	view →
UCEC	All	II,III,IV	+0.992	<.001	6	view →
LUAD	Female	II,III,IV	+0.485	.002	6	view →
BRCA	Female	All	+0.451	<.001	6	view →
CHOL	All	All	+2.370	<.001	5	view →
READ	All	All	+0.778	<.001	5	view →
HNSC	All	All	+0.523	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

FAM50A–KIRC

Open the KIRC breakdown →